CATH Domain 2hl9A02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.310	TATA-Binding Protein
	3.30.310.130	Ubiquitin-related

Domain Context

CATH Clusters

Superfamily	Ubiquitin-related
Functional Family	Ubiquitin-like-specific protease 1

Enzyme Information

3.4.22.68

Ulp1 peptidase.

based on mapping to UniProt Q02724

Hydrolysis of the alpha-linked peptide bond in the sequence Gly- Gly-|-Ala-Thr-Tyr at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptide, Smt3, leading to the mature form of the protein. A second reaction involves the cleavage of an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein.

-!- The enzyme from Saccharomyces cerevisiae can also recognize small ubiquitin-like modifier 1 (SUMO-1) from human as a substrate in both SUMO-processing (alpha-linked peptide bonds) and SUMO-deconjugation (epsilon-linked peptide bonds) reactions. -!- Ulp1 has several functions, including an essential role in chromosomal segregation and progression of the cell cycle through the G2/M phase of the cell cycle. -!- Belongs to peptidase family C48.

UniProtKB Entries (1)

Q02724

ULP1_YEAST

Saccharomyces cerevisiae S288C

Ubiquitin-like-specific protease 1

PDB Structure

PDB	2HL9
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Molecular basis of the redox regulation of SUMO proteases: a protective mechanism of intermolecular disulfide linkage against irreversible sulfhydryl oxidation Xu, Z., Lam, L.S.M., Lam, L.H., Chau, S.F., Ng, T.B., Au, S.W.N. Faseb J.