CATH Domain 2h8hA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.505	SHC Adaptor Protein
	3.30.505.10	SH2 domain

Domain Context

CATH Clusters

Superfamily	SH2 domain
Functional Family	Tyrosine-protein kinase

Enzyme Information

2.7.10.2

Non-specific protein-tyrosine kinase.

based on mapping to UniProt P12931

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P12931

SRC_HUMAN

Homo sapiens

Proto-oncogene tyrosine-protein kinase Src

PDB Structure

PDB	2H8H
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Spodoptera
Primary Citation	N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5- (tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a novel, highly selective, orally available, dual-specific c-Src/Abl kinase inhibitor. Hennequin, L.F., Allen, J., Breed, J., Curwen, J., Fennell, M., Green, T.P., Lambert-van der Brempt, C., Morgentin, R., Norman, R.A., Olivier, A., Otterbein, L., Ple, P.A., Warin, N., Costello, G. J.Med.Chem.