CATH Classification

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase

Enzyme Information

2.1.1.346
U6 snRNA m(6)A methyltransferase.
based on mapping to UniProt Q86W50
S-adenosyl-L-methionine + adenine in U6 snRNA = S-adenosyl-L-homocysteine + N(6)-methyladenine in U6 snRNA.
-!- This enzyme, found in vertebrates, methylates a specific adenine in a hairpin structure of snRNA. -!- The effects of the binding of the methyltransferase to its substrate is important for the regulation of the activity of an isoform of EC 2.5.1.6, that produces S-adenosyl-L-methionine. -!- The enzyme also binds (and maybe methylates) the lncRNAs XIST and MALAT1 as well as a number of pre-mRNAs at specific positions often found in the intronic regions.
2.1.1.348
mRNA m(6)A methyltransferase.
based on mapping to UniProt Q86W50
S-adenosyl-L-methionine + adenine in mRNA = S-adenosyl-L-homocysteine + N(6)-methyladenine in mRNA.
-!- This enzyme, found in eukaryotes, methylates adenines in mRNA with the consensus sequence RRACH.

UniProtKB Entries (1)

Q86W50
MET16_HUMAN
Homo sapiens
RNA N6-adenosine-methyltransferase METTL16

PDB Structure

PDB 2H00
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The Crystal Structure of Human methyltransferase 10 domain containing protein.
Wu, H., Min, J., Zeng, H., Loppnau, P., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Plotnikov, A.N.
To be Published
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