CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.1970 |
Domain Context
CATH Clusters
| Superfamily | 3.40.50.1970 |
| Functional Family |
Enzyme Information
| 4.2.3.124 |
2-deoxy-scyllo-inosose synthase.
based on mapping to UniProt Q9S5E2
D-glucose-6-phosphate = 2-deoxy-L-scyllo-inosose + phosphate.
-!- Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including kanamycin, butirosin, neomycin and ribostamycin. -!- Requires an NAD(+) cofactor, which is transiently reduced during the reaction. -!- The enzyme from the bacterium Bacillus circulans forms a complex with the glutamine amidotransferase subunit of pyridoxal 5'-phosphate synthase (EC 4.3.3.6), which appears to stabilize the complex.
|
UniProtKB Entries (1)
| Q9S5E2 |
DOIS_BACCI
Bacillus circulans
2-deoxy-scyllo-inosose synthase
|
PDB Structure
| PDB | 2GRU |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Structure of 2-deoxy-scyllo-inosose synthase, a key enzyme in the biosynthesis of 2-deoxystreptamine-containing aminoglycoside antibiotics, in complex with a mechanism-based inhibitor and NAD+
Proteins
|