CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphoenolpyruvate Carboxykinase, domain 2
Functional Family phosphoenolpyruvate carboxykinase, cytosolic [GTP]

Enzyme Information

4.1.1.32
Phosphoenolpyruvate carboxykinase (GTP).
based on mapping to UniProt P35558
GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO(2).
-!- ITP can act as phosphate donor.

UniProtKB Entries (1)

P35558
PCKGC_HUMAN
Homo sapiens
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]

PDB Structure

PDB 2GMV
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
C-8 Modifications of 3-alkyl-1,8-dibenzylxanthines as inhibitors of human cytosolic phosphoenolpyruvate carboxykinase.
Pietranico, S.L., Foley, L.H., Huby, N., Yun, W., Dunten, P., Vermeulen, J., Wang, P., Toth, K., Ramsey, G., Gubler, M.L., Wertheimer, S.J.
Bioorg.Med.Chem.Lett.
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