CATH Domain 2g8xA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.572	Thymidylate Synthase; Chain A
	3.30.572.10	Thymidylate synthase/dCMP hydroxymethylase domain

Domain Context

CATH Clusters

Superfamily	Thymidylate synthase/dCMP hydroxymethylase domain
Functional Family	Thymidylate synthase

Enzyme Information

2.1.1.45

Thymidylate synthase.

based on mapping to UniProt P0A884

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.

UniProtKB Entries (1)

TYSY_ECOLI

Escherichia coli K-12

Thymidylate synthase

PDB Structure

PDB	2G8X
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	The role of protein dynamics in thymidylate synthase catalysis: Variants of conserved dUMP-binding Tyr-261 Newby, Z., Lee, T.T., Morse, R.J., Liu, L., Liu, Y., Venkatraman, P., Santi, D.V., Finer-Moore, J.S., Stroud, R.M. TO BE PUBLISHED