CATH Domain 2fx4A02

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Domain Context

CATH Clusters

Superfamily	Trypsin-like serine proteases
Functional Family	Cationic trypsin

Enzyme Information

3.4.21.4

Trypsin.

based on mapping to UniProt P00760

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

-!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.4.

UniProtKB Entries (1)

TRY1_BOVIN

Bos taurus

Cationic trypsin

PDB Structure

PDB	2FX4
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure-guided design of Peptide-based tryptase inhibitors. McGrath, M.E., Sprengeler, P.A., Hirschbein, B., Somoza, J.R., Lehoux, I., Janc, J.W., Gjerstad, E., Graupe, M., Estiarte, A., Venkataramani, C., Liu, Y., Yee, R., Ho, J.D., Green, M.J., Lee, C.-S., Liu, L., Tai, V., Spencer, J., Sperandio, D., Katz, B.A. Biochemistry