CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.20 | Alpha-Beta Barrel |
|
3.20.20 | TIM Barrel |
|
3.20.20.100 | NADP-dependent oxidoreductase domain |
Domain Context
CATH Clusters
| Superfamily | NADP-dependent oxidoreductase domain |
| Functional Family | Aldo-keto reductase family 1 member C3 |
Enzyme Information
| 1.1.1.225 |
Chlordecone reductase.
based on mapping to UniProt P17516
Chlordecone alcohol + NADP(+) = chlordecone + NADPH.
-!- Chlordecone, an organochlorine pesticide, is 1,1a,3,3a,4,5,5a,5b,6- decachlorooctahydro-1,3,4-metheno-2H-cyclobuta[cd]pentalen-2-one.
|
| 1.1.1.357 |
3-alpha-hydroxysteroid 3-dehydrogenase.
based on mapping to UniProt P17516
A 3-alpha-hydroxysteroid + NAD(P)(+) = a 3-oxosteroid + NAD(P)H.
-!- The enzyme acts on multiple 3-alpha-hydroxysteroids, such as androsterone and 5 alpha-dihydrotestosterone. -!- The mammalian enzymes are involved in inactivation of steroid hormones, while the bacterial enzymes are involved in steroid degradation. -!- This entry stands for enzymes whose stereo-specificity with respect to NAD(+) or NADP(+) is not known (cf. EC 1.1.1.50 and EC 1.1.1.213).
|
| 1.1.1.- |
With NAD(+) or NADP(+) as acceptor.
based on mapping to UniProt P17516
|
UniProtKB Entries (1)
| P17516 |
AK1C4_HUMAN
Homo sapiens
Aldo-keto reductase family 1 member C4
|
PDB Structure
| PDB | 2FVL |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structure of human 3-alpha hydroxysteroid/dihydrodiol dehydrogenase (AKR1C4) complexed with NADP+
To be Published
|
