CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.1360 | Gyrase A; domain 2 |
|
3.30.1360.80 | S-ribosylhomocysteinase (LuxS) |
Domain Context
CATH Clusters
| Superfamily | S-ribosylhomocysteinase (LuxS) |
| Functional Family |
Enzyme Information
| 4.4.1.21 |
S-ribosylhomocysteine lyase.
based on mapping to UniProt O34667
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5- dihydroxypentan-2,3-dione.
-!- The 4,5-dihydroxypentan-2,3-dione formed spontaneously cyclizes and combines with borate to form an autoinducer (AI-2) in the bacterial quorum-sensing mechanism, which is used by many bacteria to control gene expression in response to cell density. -!- Formerly EC 3.2.1.148 and EC 3.3.1.3.
|
UniProtKB Entries (1)
| O34667 |
LUXS_BACSU
Bacillus subtilis subsp. subtilis str. 168
S-ribosylhomocysteine lyase
|
PDB Structure
| PDB | 2FQT |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Design and Synthesis of Substrate Analogue Inhibitors of S-Ribosylhomocysteinase (LuxS)
J.Med.Chem.
|
