CATH Classification

Domain Context

CATH Clusters

Superfamily DNA integrity scanning protein, DisA, N-terminal domain
Functional Family Diadenylate cyclase

Enzyme Information

2.7.7.85
Diadenylate cyclase.
based on mapping to UniProt Q812L9
2 ATP = 2 diphosphate + cyclic di-3',5'-adenylate.
-!- Cyclic di-3',5'-adenylate is a bioactive molecule produced by some bacteria and archaea, which may function as a secondary signaling molecule. -!- The intracellular bacterial pathogen Listeria monocytogenes secretes it into the host's cytosol, where it triggers a cytosolic pathway of innate immunity.

UniProtKB Entries (1)

Q812L9
Q812L9_BACCR
Bacillus cereus ATCC 14579
Diadenylate cyclase

PDB Structure

PDB 2FB5
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The crystal structure of the hypothetical membrane spanning protein from Bacillus cereus
Zhang, R., Zhou, M., Ginell, S., Abdullah, J., Collart, F., Joachimiak, A.
To be Published
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