CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.10 | Roll |
|
3.10.450 | Nuclear Transport Factor 2; Chain: A, |
|
3.10.450.50 |
Domain Context
CATH Clusters
| Superfamily | 3.10.450.50 |
| Functional Family | Aklanonic acid methyl ester cyclase AcmA |
Enzyme Information
| 5.5.1.23 |
Aklanonic acid methyl ester cyclase.
based on mapping to UniProt O52646
Aklaviketone = methyl aklanonate.
-!- The enzyme is involved in the biosynthesis of aklaviketone, an intermediate in the biosynthetic pathways leading to formation of several anthracycline antibiotics, including aclacinomycin, daunorubicin and doxorubicin.
|
UniProtKB Entries (1)
| O52646 |
DNRD_STRGJ
Streptomyces galilaeus
Aklanonic acid methyl ester cyclase AcmA
|
PDB Structure
| PDB | 2F99 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structure of the polyketide cyclase AknH with bound substrate and product analogue: implications for catalytic mechanism and product stereoselectivity.
J.Mol.Biol.
|
