CATH Classification

Domain Context

CATH Clusters

Superfamily Golgi alpha-mannosidase II
Functional Family Alpha-xylosidase

Enzyme Information

3.2.1.177
Alpha-D-xyloside xylohydrolase.
based on mapping to UniProt P31434
Hydrolysis of terminal, non-reducing alpha-D-xylose residues with release of alpha-D-xylose.
-!- The enzyme catalyzes hydrolysis of a terminal, unsubstituted xyloside at the extreme reducing end of a xylogluco-oligosaccharide. -!- Representative alpha-xylosidases from glycoside hydrolase family 31 utilize a two-step (double-displacement) mechanism involving a covalent glycosyl-enzyme intermediate, and retain the anomeric configuration of the product.

UniProtKB Entries (1)

P31434
XYLS_ECOLI
Escherichia coli K-12
Alpha-xylosidase

PDB Structure

PDB 2F2H
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Expanding the Thioglycoligase Strategy to the Synthesis of alpha-linked Thioglycosides Allows Structural Investigation of the Parent Enzyme/Substrate Complex
Kim, Y.-W., Lovering, A.L., Chen, H., Kantner, T., McIntosh, L.P., Strynadka, N.C.J., Withers, S.G.
J.Am.Chem.Soc.
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