CATH Classification
Level | CATH Code | Description |
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3 | Alpha Beta |
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3.40 | 3-Layer(aba) Sandwich |
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3.40.1010 | Cobalt-precorrin-4 Transmethylase; domain 1 |
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3.40.1010.10 | Cobalt-precorrin-4 Transmethylase; Domain 1 |
Domain Context
CATH Clusters
Superfamily | Cobalt-precorrin-4 Transmethylase; Domain 1 |
Functional Family | Putative diphthine synthase |
Enzyme Information
2.1.1.98 |
Diphthine synthase.
based on mapping to UniProt O58456
3 S-adenosyl-L-methionine + 2-((3S)-3-carboxy-3-aminopropyl)-L-histidine- [translation elongation factor 2] = 3 S-adenosyl-L-homocysteine + diphthine-[translation elongation factor 2].
-!- This archaeal enzyme produces the trimethylated product diphthine, which is converted into diphthamide by EC 6.3.1.14. -!- Different from the eukaryotic enzyme, which produces diphthine methyl ester (cf. EC 2.1.1.314). -!- In the archaeon Pyrococcus horikoshii the enzyme acts on His(600) of elongation factor 2.
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UniProtKB Entries (1)
O58456 |
DPHB_PYRHO
Pyrococcus horikoshii OT3
Diphthine synthase
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PDB Structure
PDB | 2ED3 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Escherichia |
Primary Citation |
Mutant I127M structure of PH0725 from Pyrococcus horikoshii OT3
To be Published
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