CATH Domain 2e9oA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	Serine/threonine-protein kinase Chk1

Enzyme Information

2.7.11.1

Non-specific serine/threonine protein kinase.

based on mapping to UniProt O14757

ATP + a protein = ADP + a phosphoprotein.

-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

O14757

CHK1_HUMAN

Homo sapiens

Serine/threonine-protein kinase Chk1

PDB Structure

PDB	2E9O
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Discovery of 1,4-dihydroindeno[1,2-c]pyrazoles as a novel class of potent and selective checkpoint kinase 1 inhibitors. Tong, Y., Claiborne, A., Stewart, K.D., Park, C., Kovar, P., Chen, Z., Credo, R.B., Gu, W.Z., Gwaltney, S.L., Judge, R.A., Zhang, H., Rosenberg, S.H., Sham, H.L., Sowin, T.J., Lin, N.H. Bioorg.Med.Chem.