CATH Domain 2e8uA00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.600	Farnesyl Diphosphate Synthase
	1.10.600.10	Farnesyl Diphosphate Synthase

Domain Context

CATH Clusters

Superfamily	Farnesyl Diphosphate Synthase
Functional Family	Geranylgeranyl pyrophosphate synthase

Enzyme Information

2.5.1.-	Transferring alkyl or aryl groups, other than methyl groups. based on mapping to UniProt Q12051
2.5.1.10	(2E,6E)-farnesyl diphosphate synthase. based on mapping to UniProt Q12051 Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)- farnesyl diphosphate. -!- Some forms of this enzyme will also use dimethylallyl diphosphate as a substrate. -!- The enzyme will not accept larger prenyl diphosphates as efficient donors.
2.5.1.29	Geranylgeranyl diphosphate synthase. based on mapping to UniProt Q12051 (2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate. -!- Some forms of this enzyme will also use geranyl diphosphate and dimethylallyl diphosphate as donors; it will not use larger prenyl diphosphates as efficient donors.
2.5.1.1	Dimethylallyltranstransferase. based on mapping to UniProt Q12051 Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate. -!- Will not accept larger prenyl diphosphates as efficient donors.

UniProtKB Entries (1)

GGPPS_YEAST

Saccharomyces cerevisiae S288C

Geranylgeranyl pyrophosphate synthase

PDB Structure

PDB	2E8U
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases Guo, R.T., Cao, R., Liang, P.H., Ko, T.P., Chang, T.H., Hudock, M.P., Jeng, W.Y., Chen, C.K.-M., Zhang, Y., Song, Y., Kuo, C.J., Yin, F., Oldfield, E., Wang, A.H.-J. Proc.Natl.Acad.Sci.Usa