CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.930 | BirA Bifunctional Protein; domain 2 |
|
3.30.930.10 | Bira Bifunctional Protein; Domain 2 |
Domain Context
CATH Clusters
| Superfamily | Bira Bifunctional Protein; Domain 2 |
| Functional Family |
Enzyme Information
| 6.1.1.27 |
O-phosphoserine--tRNA ligase.
based on mapping to UniProt O30126
ATP + O-phospho-L-serine + tRNA(Cys) = AMP + diphosphate + O-phospho-L- seryl-tRNA(Cys).
-!- In organisms like Archaeoglobus fulgidus lacking EC 6.1.1.16 for the direct Cys-tRNA(Cys) formation, Cys-tRNA(Cys) is produced by an indirect pathway, in which EC 6.1.1.27 ligates O-phosphoserine to tRNA(Cys), and EC 2.5.1.73 converts the produced O-phospho-L-seryl- tRNA(Cys) to Cys-tRNA(Cys). -!- The SepRS/SepCysS pathway is the sole route for cysteine biosynthesis in the organism. -!- Methanosarcina mazei can use both pathways, the direct route using EC 6.1.1.16 and the indirect pathway with EC 6.1.1.27 and EC 2.5.1.73. -!- Formerly EC 6.1.1.n2.
|
UniProtKB Entries (1)
| O30126 |
SEPS_ARCFU
Archaeoglobus fulgidus DSM 4304
O-phosphoserine--tRNA(Cys) ligase
|
PDB Structure
| PDB | 2DU5 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Structural insights into the first step of RNA-dependent cysteine biosynthesis in archaea.
Nat.Struct.Mol.Biol.
|
