CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.90 | Alpha-Beta Complex |
|
3.90.1760 | Adenylylcyclase toxin fold |
|
3.90.1760.10 | Anthrax toxin, edema factor, central domain |
Domain Context
CATH Clusters
| Superfamily | Anthrax toxin, edema factor, central domain |
| Functional Family |
Enzyme Information
| 4.6.1.1 |
Adenylate cyclase.
based on mapping to UniProt P0DKX7
ATP = 3',5'-cyclic AMP + diphosphate.
-!- Also acts on dATP to form 3',5'-cyclic dAMP. -!- Requires pyruvate. -!- Activated by NAD(+) in presence of EC 2.4.2.31.
|
UniProtKB Entries (2)
| P0DP34 |
CAM2A_XENLA
Xenopus laevis
Calmodulin-2 A
|
| P0DKX7 |
CYAA_BORPE
Bordetella pertussis Tohama I
Bifunctional hemolysin/adenylate cyclase
|
PDB Structure
| PDB | 2COL |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Structural basis for the interaction of Bordetella pertussis adenylyl cyclase toxin with calmodulin
Embo J.
|
