CATH Classification

Domain Context

CATH Clusters

Superfamily Cysteine Rich Protein
Functional Family F-actin-monooxygenase MICAL1 isoform 1

Enzyme Information

1.14.13.225
F-actin monooxygenase.
based on mapping to UniProt Q8TDZ2
[F-actin]-L-methionine + NADPH + O(2) + H(+) = [F-actin]-L-methionine- (R)-S-oxide + NADP(+) + H(2)O.
-!- The enzyme, characterized from the fruit fly Drosophila melanogaster, is a multi-domain oxidoreductase that acts as an F-actin disassembly factor. -!- The enzyme selectively reduces two L-Met residues of F-actin, causing fragmentation of the filaments and preventing repolymerization. -!- Free methionine is not a substrate. -!- The reaction is stereospecific and generates the (R)-sulfoxide.

UniProtKB Entries (1)

Q8TDZ2
MICA1_HUMAN
Homo sapiens
[F-actin]-monooxygenase MICAL1

PDB Structure

PDB 2CO8
External Links
Method SOLUTION NMR
Organism
Primary Citation
Solution structures of the LIM domain of human NEDD9 interacting protein with calponin homology and LIM domains
Sato, M., Tomizawa, T., Saito, K., Koshiba, S., Inoue, M., Kigawa, T., Yokoyama, S.
To be Published