CATH Classification
Level | CATH Code | Description |
---|---|---|
2 | Mainly Beta | |
2.10 | Ribbon | |
2.10.110 | Cysteine Rich Protein | |
2.10.110.10 | Cysteine Rich Protein |
Domain Context
CATH Clusters
Superfamily | Cysteine Rich Protein |
Functional Family | F-actin-monooxygenase MICAL1 isoform 1 |
Enzyme Information
1.14.13.225 |
F-actin monooxygenase.
based on mapping to UniProt Q8TDZ2
[F-actin]-L-methionine + NADPH + O(2) + H(+) = [F-actin]-L-methionine- (R)-S-oxide + NADP(+) + H(2)O.
-!- The enzyme, characterized from the fruit fly Drosophila melanogaster, is a multi-domain oxidoreductase that acts as an F-actin disassembly factor. -!- The enzyme selectively reduces two L-Met residues of F-actin, causing fragmentation of the filaments and preventing repolymerization. -!- Free methionine is not a substrate. -!- The reaction is stereospecific and generates the (R)-sulfoxide.
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UniProtKB Entries (1)
Q8TDZ2 |
MICA1_HUMAN
Homo sapiens
[F-actin]-monooxygenase MICAL1
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PDB Structure
PDB | 2CO8 |
External Links | |
Method | SOLUTION NMR |
Organism | |
Primary Citation |
Solution structures of the LIM domain of human NEDD9 interacting protein with calponin homology and LIM domains
To be Published
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