CATH Domain 2chmA00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.1300	Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b
	1.10.1300.10	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain

Domain Context

CATH Clusters

Superfamily	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Functional Family	Phosphodiesterase

Enzyme Information

3.1.4.35

3',5'-cyclic-GMP phosphodiesterase.

based on mapping to UniProt O76074

Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate.

3.1.4.53

3',5'-cyclic-AMP phosphodiesterase.

based on mapping to UniProt Q07343

Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate.

-!- Specific for 3',5'-cAMP and does not hydrolyze other nucleoside 3',5'-cyclic phosphates such as cGMP (cf. EC 3.1.4.17 and EC 3.1.4.35). -!- It is involved in modulation of the levels of cAMP, which is a mediator in the processes of cell transformation and proliferation. -!- Formerly EC 3.1.4.n1.

UniProtKB Entries (1)

O76074

PDE5A_HUMAN

Homo sapiens

CGMP-specific 3',5'-cyclic phosphodiesterase

PDB Structure

PDB	2CHM
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	A Novel Series of Potent and Selective Pde5 Inhibitors with Potential for High and Dose-Independent Oral Bioavailability Allerton, C.M.N., Barber, C.G., Beaumont, K.C., Brown, D.G., Cole, S.M., Ellis, D., Lane, C.A.L., Maw, G.N., Mount, N.M., Rawson, D.J., Robinson, C.M., Street, S.D.A., Summerhill, N.W. J.Med.Chem.