CATH Classification

Domain Context

CATH Clusters

Superfamily Acetylglutamate kinase-like
Functional Family Aspartokinase

Enzyme Information

2.7.2.4
Aspartate kinase.
based on mapping to UniProt Q9LYU8
ATP + L-aspartate = ADP + 4-phospho-L-aspartate.
-!- The enzyme from Escherichia coli is a multifunctional protein, which also catalyzes the reaction of EC 1.1.1.3. -!- This is also the case for two of the four isoenzymes in Arabidopsis thaliana. -!- The equilibrium constant strongly favors the reaction from right to left, i.e. the non-physiological direction of reaction.

UniProtKB Entries (1)

Q9LYU8
AK1_ARATH
Arabidopsis thaliana
Aspartokinase 1, chloroplastic

PDB Structure

PDB 2CDQ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A Novel Organization of Act Domains in Allosteric Enzymes Revealed by the Crystal Structure of Arabidopsis Aspartate Kinase
Mas-Droux, C., Curien, G., Robert-Genthon, M., Laurencin, M., Ferrer, J.L., Dumas, R.
Plant Cell