CATH Classification

Domain Context

CATH Clusters

Superfamily Set2, Rpb1 interacting domain
Functional Family Histone-lysine N-methyltransferase

Enzyme Information

2.1.1.43
Histone-lysine N-methyltransferase.
based on mapping to UniProt P46995
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

UniProtKB Entries (1)

P46995
SET2_YEAST
Saccharomyces cerevisiae S288C
Histone-lysine N-methyltransferase, H3 lysine-36 specific

PDB Structure

PDB 2C5Z
External Links
Method SOLUTION NMR
Organism
Primary Citation
Structure and carboxyl-terminal domain (CTD) binding of the Set2 SRI domain that couples histone H3 Lys36 methylation to transcription.
Vojnic, E., Simon, B., Strahl, B.D., Sattler, M., Cramer, P.
J. Biol. Chem.