CATH Domain 2c4fH01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Domain Context

CATH Clusters

Superfamily	Trypsin-like serine proteases
Functional Family

Enzyme Information

3.4.21.21

Coagulation factor VIIa.

based on mapping to UniProt P08709

Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.

-!- Formed from the precursor factor VII. -!- The cattle enzyme is more readily inhibited by diisopropyl fluorophosphate than the human. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P13726

TF_HUMAN

Homo sapiens

Tissue factor

PDB Structure

PDB	2C4F
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The Discovery of Fluoropyridine-Based Inhibitors of the Factor Viia/Tf Complex--Part 2 Kohrt, J.T., Filipski, K.J., Cody, W.L., Cai, C., Dudley, D.A., Huis, C.A.V., Willardsen, J.A., Narasimhan, L.S., Zhang, E., Rapundalo, S.T., Saiya-Cork, K., Leadley, R.J., Edmunds, J.J. Bioorg.Med.Chem.Lett.