CATH Classification
Level | CATH Code | Description |
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3 | Alpha Beta |
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3.40 | 3-Layer(aba) Sandwich |
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3.40.50 | Rossmann fold |
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3.40.50.920 |
Domain Context
CATH Clusters
Superfamily | 3.40.50.920 |
Functional Family | Pyruvate:ferredoxin (Flavodoxin) oxidoreductase |
Enzyme Information
1.2.7.1 |
Pyruvate synthase.
based on mapping to UniProt P94692
Pyruvate + CoA + 2 oxidized ferredoxin = acetyl-CoA + CO(2) + 2 reduced ferredoxin + 2 H(+).
-!- The enzyme also decarboxylates 2-oxobutanoate with lower efficiency, but shows no activity with 2-oxoglutarate. -!- This enzyme is a member of the 2-oxoacid oxidoreductases, a family of enzymes that oxidatively decarboxylate different 2-oxoacids to form their CoA derivatives, and are differentiated based on their substrate specificity. -!- For examples of other members of this family, see EC 1.2.7.3 and EC 1.2.7.7.
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UniProtKB Entries (1)
P94692 |
PFOR_DESAF
Desulfovibrio africanus
Pyruvate:ferredoxin oxidoreductase
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PDB Structure
PDB | 2C3P |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Flexibility of Thiamine Diphosphate Revealed by Kinetic Crystallographic Studies of the Reaction of Pyruvate-Ferredoxin Oxidoreductase with Pyruvate.
Structure
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