CATH Domain 2c2dA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.1170	MutS, DNA mismatch repair protein, domain I
	3.40.1170.60

Domain Context

CATH Clusters

Superfamily	3.40.1170.60
Functional Family	DNA polymerase IV

Enzyme Information

2.7.7.7

DNA-directed DNA polymerase.

based on mapping to UniProt Q97W02

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (1)

Q97W02

DPO4_SACS2

Saccharolobus solfataricus P2

DNA polymerase IV

PDB Structure

PDB	2C2D
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Efficient and High Fidelity Incorporation of Dctp Opposite 7,8-Dihydro-8-Oxodeoxyguanosine by Sulfolobus Solfataricus DNA Polymerase Dpo4 Zang, H., Irimia, A., Choi, J.-Y., Angel, K.C., Loukachevitch, L.V., Egli, M., P Guengerich, F. J.Biol.Chem.