CATH Domain 2c0tA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.505	SHC Adaptor Protein
	3.30.505.10	SH2 domain

Domain Context

CATH Clusters

Superfamily	SH2 domain
Functional Family	Tyrosine-protein kinase

Enzyme Information

2.7.10.2

Non-specific protein-tyrosine kinase.

based on mapping to UniProt P08631

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P08631

HCK_HUMAN

Homo sapiens

Tyrosine-protein kinase HCK

PDB Structure

PDB	2C0T
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of A-770041, a Src-Family Selective Orally Active Lck Inhibitor that Prevents Organ Allograft Rejection. Burchat, A., Borhani, D.W., Calderwood, D.J., Hirst, G.C., Li, B., Stachlewitz, R.F. Bioorg.Med.Chem.Lett.