CATH Domain 2c0aC00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.20	Alpha-Beta Barrel
	3.20.20	TIM Barrel
	3.20.20.70	Aldolase class I

Domain Context

CATH Clusters

Superfamily	Aldolase class I
Functional Family	KHG/KDPG aldolase

Enzyme Information

4.1.3.16	4-hydroxy-2-oxoglutarate aldolase. based on mapping to UniProt P0A955 4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate. -!- The enzymes from rat liver and bovine liver act on both enantiomers of 4-hydroxy-2-oxoglutarate. -!- Formerly EC 4.1.2.1 and EC 4.1.2.31.
4.1.2.14	2-dehydro-3-deoxy-phosphogluconate aldolase. based on mapping to UniProt P0A955 2-dehydro-3-deoxy-6-phosphate-D-gluconate = pyruvate + D-glyceraldehyde 3-phosphate. -!- The enzyme shows no activity with 2-dehydro-3-deoxy-6-phosphate-D- galactonate (cf. EC 4.1.2.55). -!- Also acts on 2-oxobutanoate.

UniProtKB Entries (1)

ALKH_ECOLI

Escherichia coli K-12

KHG/KDPG aldolase

PDB Structure

PDB	2C0A
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Mechanism of the Class I Kdpg Aldolase. Fullerton, S.W.B., Griffiths, J.S., Merkel, A.B., Cheriyann, M., Wymer, J., Hutchins, M.J., Fierke, C.A., Toone, E.J., Naismith, J.H. Bioorg.Med.Chem.