CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.430 | Dihydrofolate Reductase, subunit A |
|
3.40.430.10 | Dihydrofolate Reductase, subunit A |
Domain Context
CATH Clusters
| Superfamily | Dihydrofolate Reductase, subunit A |
| Functional Family | Bifunctional dihydrofolate reductase-thymidylate synthase |
Enzyme Information
| 2.1.1.45 |
Thymidylate synthase.
based on mapping to UniProt O02604
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.
|
| 1.5.1.3 |
Dihydrofolate reductase.
based on mapping to UniProt O02604
5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH.
-!- The enzyme from animals and some micro-organisms also slowly reduces folate to 5,6,7,8-tetrahydrofolate. -!- Formerly EC 1.5.1.4.
|
UniProtKB Entries (1)
| O02604 |
DRTS_PLAVI
Plasmodium vivax
Bifunctional dihydrofolate reductase-thymidylate synthase
|
PDB Structure
| PDB | 2BLB |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal Structure of Dihydrofolate Reductase from Plasmodium Vivax: Pyrimethamine Displacement Linked with Mutation-Induced Resistance.
Proc.Natl.Acad.Sci.USA
|
