CATH Domain 2be5A02

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.170	Beta Complex
	2.170.120	RNA Polymerase Alpha Subunit; Chain A, domain 2
	2.170.120.12	DNA-directed RNA polymerase, insert domain

Domain Context

CATH Clusters

Superfamily	DNA-directed RNA polymerase, insert domain
Functional Family	DNA-directed RNA polymerase subunit alpha

Enzyme Information

2.7.7.6

DNA-directed RNA polymerase.

based on mapping to UniProt Q5SHR6

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.

UniProtKB Entries (1)

Q5SKW1

Q5SKW1_THET8

Thermus thermophilus HB8

RNA polymerase sigma factor SigA

PDB Structure

PDB	2BE5
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural basis for transcription inhibition by tagetitoxin Vassylyev, D.G., Svetlov, V., Vassylyeva, M.N., Perederina, A., Igarashi, N., Matsugaki, N., Wakatsuki, S., Artsimovitch, I. Nat.Struct.Mol.Biol.