CATH Domain 2b76A02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.700	Flavocytochrome C3; Chain A, domain 1
	3.90.700.10	Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain

Domain Context

CATH Clusters

Superfamily	Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
Functional Family	Fumarate reductase flavoprotein subunit

Enzyme Information

1.3.5.4

Fumarate reductase (quinol).

based on mapping to UniProt P00363

Succinate + a quinone = fumarate + a quinol.

-!- The enzyme, which is found in anaerobic and facultative organisms such as bacteria, parasitic helminthes, and lower marine organisms, utilizes low potential quinols, such as menaquinol and rhodoquinol, to reduce fumarate as the final step of an anaerobic respiratory chain. -!- The enzyme is known as complex II of the electron transfer chain, similarly to EC 1.3.5.1, to which it is closely related.

UniProtKB Entries (1)

P0A8Q0

FRDC_ECOLI

Escherichia coli K-12

Fumarate reductase subunit C

PDB Structure

PDB	2B76
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Fumarate Reductase and Succinate Oxidase Activity of Escherichia coli Complex II Homologs Are Perturbed Differently by Mutation of the Flavin Binding Domain Maklashina, E., Iverson, T.M., Sher, Y., Kotlyar, V., Andrell, J., Mirza, O., Hudson, J.M., Armstrong, F.A., Rothery, R.A., Weiner, J.H., Cecchini, G. J.Biol.Chem.