CATH Classification

Domain Context

CATH Clusters

Superfamily Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain
Functional Family Leucine--tRNA ligase

Enzyme Information

6.1.1.4
Leucine--tRNA ligase.
based on mapping to UniProt P07813
ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).

UniProtKB Entries (1)

P07813
SYL_ECOLI
Escherichia coli K-12
Leucine--tRNA ligase

PDB Structure

PDB 2AJG
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structures of the editing domain of Escherichia coli leucyl-tRNA synthetase and its complexes with Met and Ile reveal a lock-and-key mechanism for amino acid discrimination
Liu, Y., Liao, J., Zhu, B., Wang, E.D., Ding, J.
Biochem.J.