CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.20 | Up-down Bundle |
|
1.20.5 | Single alpha-helices involved in coiled-coils or other helix-helix interfaces |
|
1.20.5.1610 |
Domain Context
CATH Clusters
| Superfamily | 1.20.5.1610 |
| Functional Family |
Enzyme Information
| 2.3.1.226 |
Carboxymethylproline synthase.
based on mapping to UniProt Q9XB60
Malonyl-CoA + (S)-1-pyrroline-5-carboxylate + H(2)O = CoA + (2S,5S)-5- carboxymethylproline + CO(2).
-!- The enzyme is involved in the biosynthesis of the carbapenem beta- lactam antibiotic (5R)-carbapen-2-em-3-carboxylate in the bacterium Pectobacterium carotovorum.
|
UniProtKB Entries (1)
| Q9XB60 |
CARB_PECCC
Pectobacterium carotovorum subsp. carotovorum
Carboxymethylproline synthase
|
PDB Structure
| PDB | 2A81 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Structural and Mechanistic Studies on Carboxymethylproline Synthase (CarB), a Unique Member of the Crotonase Superfamily Catalyzing the First Step in Carbapenem Biosynthesis.
J.Biol.Chem.
|