CATH Classification

Domain Context

CATH Clusters

Superfamily 1.20.5.1610
Functional Family

Enzyme Information

2.3.1.226
Carboxymethylproline synthase.
based on mapping to UniProt Q9XB60
Malonyl-CoA + (S)-1-pyrroline-5-carboxylate + H(2)O = CoA + (2S,5S)-5- carboxymethylproline + CO(2).
-!- The enzyme is involved in the biosynthesis of the carbapenem beta- lactam antibiotic (5R)-carbapen-2-em-3-carboxylate in the bacterium Pectobacterium carotovorum.

UniProtKB Entries (1)

Q9XB60
CARB_PECCC
Pectobacterium carotovorum subsp. carotovorum
Carboxymethylproline synthase

PDB Structure

PDB 2A81
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural and Mechanistic Studies on Carboxymethylproline Synthase (CarB), a Unique Member of the Crotonase Superfamily Catalyzing the First Step in Carbapenem Biosynthesis.
Sleeman, M.C., Sorensen, J.L., Batchelar, E.T., McDonough, M.A., Schofield, C.J.
J.Biol.Chem.