CATH Classification
Level | CATH Code | Description |
---|---|---|
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3 | Alpha Beta |
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3.20 | Alpha-Beta Barrel |
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3.20.20 | TIM Barrel |
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3.20.20.80 | Glycosidases |
Domain Context
CATH Clusters
Superfamily | Glycosidases |
Functional Family | Endochitinase B1 |
Enzyme Information
3.2.1.14 |
Chitinase.
based on mapping to UniProt Q873X9
Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta- linkages in chitin and chitodextrins.
-!- The enzyme binds to chitin and randomly cleaves glycosidic linkages in chitin and chitodextrins in a non-processive mode, generating chitooligosaccharides and free ends on which exo-chitinases and exo- chitodextrinases can act. -!- Activity is greatly stimulated in the presence of EC 1.14.99.53, which attacks the crystalline structure of chitin and makes the polymer more accesible to the chitinase. -!- Cf. EC 3.2.1.202.
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UniProtKB Entries (1)
Q873X9 |
CHIB1_ASPFM
Aspergillus fumigatus
Endochitinase B1
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PDB Structure
PDB | 2A3E |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Escherichia |
Primary Citation |
Methylxanthine drugs are chitinase inhibitors: investigation of inhibition and binding modes.
Chem.Biol.
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