CATH Domain 1zyrD05

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.274	Enzyme I; Chain A, domain 2
	1.10.274.100	RNA polymerase Rpb1, domain 3

Domain Context

CATH Clusters

Superfamily	RNA polymerase Rpb1, domain 3
Functional Family

Enzyme Information

2.7.7.6

DNA-directed RNA polymerase.

based on mapping to UniProt Q8RQE8

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.

UniProtKB Entries (1)

Q5SHR6

RPOA_THET8

Thermus thermophilus HB8

DNA-directed RNA polymerase subunit alpha

PDB Structure

PDB	1ZYR
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation. Tuske, S., Sarafianos, S.G., Wang, X., Hudson, B., Sineva, E., Mukhopadhyay, J., Birktoft, J.J., Leroy, O., Ismail, S., Clark, A.D., Dharia, C., Napoli, A., Laptenko, O., Lee, J., Borukhov, S., Ebright, R.H., Arnold, E. Cell(Cambridge,Mass.)