CATH Domain 1ztbA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.60	4-Layer Sandwich
	3.60.150	Chorismate synthase, AroC fold
	3.60.150.10	Chorismate synthase AroC

Domain Context

CATH Clusters

Superfamily	Chorismate synthase AroC
Functional Family	Chorismate synthase

Enzyme Information

4.2.3.5

Chorismate synthase.

based on mapping to UniProt P9WPY1

5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate.

-!- The reaction goes via a radical mechanism that involves reduced FMN and its semiquinone (FMNH.). -!- Shikimate is numbered so that the double-bond is between C-1 and C-2, but some earlier papers numbered the ring in the reverse direction. -!- Formerly EC 4.6.1.4.

UniProtKB Entries (1)

P9WPY1

AROC_MYCTU

Mycobacterium tuberculosis H37Rv

Chorismate synthase

PDB Structure

PDB	1ZTB
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Structure of chorismate synthase from Mycobacterium tuberculosis Dias, M.V.B., Borges, J.C., Ely, F., Pereira, J.H., Canduri, F., Ramos, C.H.I., Frazzon, J., Palma, M.S., Basso, L.A., Santos, D.S., de Azevedo Jr., W.F. J.Struct.Biol.