CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.10 | Roll |
|
3.10.20 | Ubiquitin-like (UB roll) |
|
3.10.20.810 | Phosphoribosyl-AMP cyclohydrolase |
Domain Context
CATH Clusters
| Superfamily | Phosphoribosyl-AMP cyclohydrolase |
| Functional Family | Histidine biosynthesis bifunctional protein HisIE |
Enzyme Information
| 3.5.4.19 |
Phosphoribosyl-AMP cyclohydrolase.
based on mapping to UniProt O26347
1-(5-phospho-beta-D-ribosyl)-AMP + H(2)O = 1-(5-phospho-beta-D-ribosyl)- 5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4- carboxamide.
-!- The Neurospora crassa enzyme also catalyzes the reactions of EC 1.1.1.23 and EC 3.6.1.31.
|
UniProtKB Entries (1)
| O26347 |
HIS3_METTH
Methanothermobacter thermautotrophicus str. Delta H
Phosphoribosyl-AMP cyclohydrolase
|
PDB Structure
| PDB | 1ZPS |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal Structure of Methanobacterium thermoautotrophicum Phosphoribosyl-AMP Cyclohydrolase HisI.
Biochemistry
|
