CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.40 | 3-Layer(aba) Sandwich | |
3.40.1160 | Carbamate kinase | |
3.40.1160.10 | Acetylglutamate kinase-like |
Domain Context
CATH Clusters
Superfamily | Acetylglutamate kinase-like |
Functional Family | Uridylate kinase |
Enzyme Information
2.7.4.22 |
UMP kinase.
based on mapping to UniProt P65938
ATP + UMP = ADP + UDP.
-!- Strictly specific for UMP as substrate and is used by prokaryotes in the de novo synthesis of pyrimidines, in contrast to eukaryotes, which use the dual-specificity enzyme EC 2.7.4.14 for the same purpose. -!- Subject of feedback regulation, being inhibited by UTP and activated by GTP.
|
UniProtKB Entries (1)
P65938 |
PYRH_STRP1
Streptococcus pyogenes serotype M1
Uridylate kinase
|
PDB Structure
PDB | 1Z9D |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Escherichia |
Primary Citation |
Crystal structure of a putative uridylate kinase (UMP-kinase) from Streptococcus pyogenes
To be Published
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