CATH Classification

Domain Context

CATH Clusters

Superfamily Acetylglutamate kinase-like
Functional Family Uridylate kinase

Enzyme Information

2.7.4.22
UMP kinase.
based on mapping to UniProt P65938
ATP + UMP = ADP + UDP.
-!- Strictly specific for UMP as substrate and is used by prokaryotes in the de novo synthesis of pyrimidines, in contrast to eukaryotes, which use the dual-specificity enzyme EC 2.7.4.14 for the same purpose. -!- Subject of feedback regulation, being inhibited by UTP and activated by GTP.

UniProtKB Entries (1)

P65938
PYRH_STRP1
Streptococcus pyogenes serotype M1
Uridylate kinase

PDB Structure

PDB 1Z9D
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of a putative uridylate kinase (UMP-kinase) from Streptococcus pyogenes
Rajashankar, K.R., Kniewel, R., Lee, K., Lima, C.D.
To be Published