CATH Classification

Domain Context

CATH Clusters

Superfamily Histidine kinase-like ATPase, C-terminal domain
Functional Family Type 2 DNA topoisomerase 6 subunit B

Enzyme Information

5.6.2.3
DNA topoisomerase (ATP-hydrolyzing).
based on mapping to UniProt O05207
ATP-dependent breakage, passage and rejoining of double-stranded DNA.
-!- The enzyme can introduce negative superhelical turns into double- stranded circular DNA. -!- One unit has nicking-closing activity, and another catalyzes super- twisting and hydrolysis of ATP (cf. EC 5.6.2.2). -!- Formerly EC 5.99.1.3.

UniProtKB Entries (1)

O05207
TOP6B_SACSH
Saccharolobus shibatae
Type 2 DNA topoisomerase 6 subunit B

PDB Structure

PDB 1Z5B
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural dissection of ATP turnover in the prototypical GHL ATPase TopoVI.
Corbett, K.D., Berger, J.M.
Structure
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