CATH Domain 1ywoA00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.30	Roll
	2.30.30	SH3 type barrels.
	2.30.30.40	SH3 Domains

Domain Context

CATH Clusters

Superfamily	SH3 Domains
Functional Family	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma

Enzyme Information

3.1.4.11

Phosphoinositide phospholipase C.

based on mapping to UniProt P10686

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.

-!- These enzymes form some of the cyclic phosphate Ins(cyclic 1,2)P(4,5)P(2) as well as Ins(1,4,5)P(3). -!- They show activity toward phosphatidylinositol, i.e., the activity of EC 4.6.1.13 in vitro at high calcium concentration.

UniProtKB Entries (2)

P10686	PLCG1_RAT Rattus norvegicus 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
Q13094	LCP2_HUMAN Homo sapiens Lymphocyte cytosolic protein 2

PDB Structure

PDB	1YWO
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Structural Basis for Recognition of the T Cell Adaptor Protein SLP-76 by the SH3 Domain of Phospholipase Cgamma1 Deng, L., Velikovsky, C.A., Swaminathan, C.P., Cho, S., Mariuzza, R.A. J.Mol.Biol.