CATH Domain 1xjoA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.630	Aminopeptidase
	3.40.630.10	Zn peptidases

Domain Context

CATH Clusters

Superfamily	Zn peptidases
Functional Family	M28 family peptidase

Enzyme Information

3.4.11.24

Aminopeptidase S.

based on mapping to UniProt P80561

Release of an N-terminal amino acid with a preference for large hydrophobic amino-terminus residues.

-!- Activated by Ca(2+). -!- In the presence of Ca(2+), the best substrates are Leu-Phe, Leu-Ser, Leu-pNA (aminoacyl-p-nitroanilide), Phe-Phe-Phe and Phe-Phe. -!- Peptides with proline in the P1' position are not substrates. -!- Belongs to peptidase family M28. -!- Formerly EC 3.4.11.n1.

UniProtKB Entries (1)

P80561

APX_STRGG

Streptomyces griseus subsp. griseus NBRC 13350

Aminopeptidase S

PDB Structure

PDB	1XJO
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Streptomyces griseus aminopeptidase: X-ray crystallographic structure at 1.75 A resolution. Greenblatt, H.M., Almog, O., Maras, B., Spungin-Bialik, A., Barra, D., Blumberg, S., Shoham, G. J.Mol.Biol.