CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.200 | Peptidase S8/S53 domain |
Domain Context
CATH Clusters
| Superfamily | Peptidase S8/S53 domain |
| Functional Family |
Enzyme Information
| 3.4.21.110 |
C5a peptidase.
based on mapping to UniProt P15926
The primary cleavage site is at 67-His-|-Lys-68 in human C5a with a minor secondary cleavage site at 58-Ala-|-Ser-59.
-!- Surface-associated subtilisin-like serine peptidase with very specific substrate specificity. -!- Virulent strains of streptococci, including Streptococcus pyogenes, can evade human detection and phagocytosis by destroying the complement chemotaxin C5a. -!- Cleavage of human C5a by this enzyme reduces the ability of C5a to bind receptors on the surface of polymorphonuclear neutrophil leukocytes (PMNLs) and thereby abolishes its chemotactic properties. -!- Belongs to peptidase family S8A.
|
UniProtKB Entries (1)
| P15926 |
C5AP_STRPY
Streptococcus pyogenes
C5a peptidase
|
PDB Structure
| PDB | 1XF1 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Structure of the streptococcal cell wall C5a peptidase
Proc.Natl.Acad.Sci.Usa
|