CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.390 | Enolase-like; domain 1 |
|
3.30.390.30 | FAD/NAD-linked reductase, C-terminal dimerisation domain |
Domain Context
CATH Clusters
| Superfamily | 3.30.390.30 |
| Functional Family | Flavoprotein disulfide reductase |
Enzyme Information
| 1.6.5.2 |
NAD(P)H dehydrogenase (quinone).
based on mapping to UniProt P9WHH7
NAD(P)H + a quinone = NAD(P)(+) + a hydroquinone.
-!- The enzyme catalyzes a two-electron reduction and has a preference for short-chain acceptor quinones, such as ubiquinone, benzoquinone, juglone and duroquinone. -!- The animal, but not the plant, form of the enzyme is inhibited by dicoumarol. -!- Formerly EC 1.6.99.2.
|
UniProtKB Entries (1)
| P9WHH7 |
LPDA_MYCTU
Mycobacterium tuberculosis H37Rv
NAD(P)H dehydrogenase (quinone)
|
PDB Structure
| PDB | 1XDI |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Characterization of a New Member of the Flavoprotein Disulfide Reductase Family of Enzymes from Mycobacterium tuberculosis
J.Biol.Chem.
|
