CATH Domain 1wsrA03

CATH Classification

Level	CATH Code	Description
	4	Few Secondary Structures
	4.10	Irregular
	4.10.1250	Aminomethyltransferase fragment
	4.10.1250.10	Aminomethyltransferase fragment

Domain Context

CATH Clusters

Superfamily	Aminomethyltransferase fragment
Functional Family	Aminomethyltransferase

Enzyme Information

2.1.2.10

Aminomethyltransferase.

based on mapping to UniProt P48728

[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH(3).

-!- A component, with EC 1.4.4.2 and EC 1.8.1.4, of the glycine cleavage system, formerly known as glycine synthase. -!- The glycine cleavage system is composed of four components that only loosely associate: the P protein (EC 1.4.4.2), the T protein (EC 2.1.2.10), the L protein (EC 1.8.1.4) and the lipoyl-bearing H protein.

UniProtKB Entries (1)

P48728

GCST_HUMAN

Homo sapiens

Aminomethyltransferase, mitochondrial

PDB Structure

PDB	1WSR
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal Structure of Human T-protein of Glycine Cleavage System at 2.0A Resolution and its Implication for Understanding Non-ketotic Hyperglycinemia Okamura-Ikeda, K., Hosaka, H., Yoshimura, M., Yamashita, E., Toma, S., Nakagawa, A., Fujiwara, K., Motokawa, Y., Taniguchi, H. J.Mol.Biol.