CATH Classification

Domain Context

CATH Clusters

Superfamily CAP Gly-rich-like domain
Functional Family Putative ubiquitin carboxyl-terminal hydrolase CYLD

Enzyme Information

3.4.19.12
Ubiquitinyl hydrolase 1.
based on mapping to UniProt Q9NQC7
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
-!- Links to polypeptides smaller than 60 residues are hydrolyzed more readily than those to larger polypeptides. -!- Isoforms exist with quantitatively different specificities among the best known being UCH-L1 and UCH-L3, major proteins of the brain of mammals. -!- Inhibited by ubiquitin aldehyde (in which Gly76 is replaced by aminoacetaldehyde). -!- Belongs to peptidase family C12.

UniProtKB Entries (1)

Q9NQC7
CYLD_HUMAN
Homo sapiens
Ubiquitin carboxyl-terminal hydrolase CYLD

PDB Structure

PDB 1WHL
External Links
Method SOLUTION NMR
Organism
Primary Citation
Solution structure of the 1st CAP-Gly domain in human cylindromatosis tumor suppressor CYLD
Saito, K., Koshiba, S., Inoue, M., Kigawa, T., Yokoyama, S.
To be Published