CATH Domain 1w7xH01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Domain Context

CATH Clusters

Superfamily	Trypsin-like serine proteases
Functional Family

Enzyme Information

3.4.21.21

Coagulation factor VIIa.

based on mapping to UniProt P08709

Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.

-!- Formed from the precursor factor VII. -!- The cattle enzyme is more readily inhibited by diisopropyl fluorophosphate than the human. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P08709

FA7_HUMAN

Homo sapiens

Coagulation factor VII

PDB Structure

PDB	1W7X
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Selective and Orally Bioavailable Phenylglycine Tissue Factor/Factor Viia Inhibitors. Zbinden, K.G., Obst-Sander, U., Hilpert, K., Kuhne, H., Banner, D.W., Bohm, H.J., Stahl, M., Ackermann, J., Alig, L., Weber, L., Wessel, H.P., Riederer, M.A., Tschopp, T.B., Lave, T. Bioorg.Med.Chem.Lett.