CATH Classification

Domain Context

CATH Clusters

Superfamily PCRA; domain 4
Functional Family RecBCD enzyme subunit RecB

Enzyme Information

3.1.11.5
Exodeoxyribonuclease V.
based on mapping to UniProt P08394
Exonucleolytic cleavage (in the presence of ATP) in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides.
-!- Preference for double-stranded DNA. -!- Possesses DNA-dependent ATPase activity. -!- Acts endonucleolytically on single-stranded circular DNA. -!- Similar enzyme: Haemophilus influenzae ATP-dependent DNase.

UniProtKB Entries (1)

P07648
RECC_ECOLI
Escherichia coli K-12
RecBCD enzyme subunit RecC

PDB Structure

PDB 1W36
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of Recbcd Enzyme Reveals a Machine for Processing DNA Breaks
Singleton, M.R., Dillingham, M.S., Gaudier, M., Kowalczykowski, S.C., Wigley, D.B.
Nature