CATH Domain 1w2zD01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.10	Roll
	3.10.450	Nuclear Transport Factor 2; Chain: A,
	3.10.450.40

Domain Context

CATH Clusters

Superfamily	3.10.450.40
Functional Family	Amine oxidase

Enzyme Information

1.4.3.21

Primary-amine oxidase.

based on mapping to UniProt Q43077

RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2).

-!- A group of enzymes that oxidize primary monoamines but have little or no activity toward diamines, such as histamine, or toward secondary and tertiary amines. -!- They are copper quinoproteins (2,4,5-trihydroxyphenylalanine quinone) and, unlike EC 1.4.3.4, are sensitive to inhibition by carbonyl-group reagents, such as semicarbazide. -!- In some mammalian tissues the enzyme also functions as a vascular- adhesion protein (VAP-1). -!- Formerly EC 1.4.3.6.

UniProtKB Entries (1)

Q43077

AMO_PEA

Pisum sativum

Primary amine oxidase

PDB Structure

PDB	1W2Z
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Using Xenon as a Probe for Dioxygen-Binding Sites in Copper Amine Oxidases. Duff, A.P., Trambaiolo, D.M., Cohen, A.E., Ellis, P.J., Juda, G.A., Shepard, E.M., Langley, D.B., Dooley, D.M., Freeman, H.C., Guss, J.M. J.Mol.Biol.