CATH Classification

Domain Context

CATH Clusters

Superfamily B-lactam Antibiotic, Isopenicillin N Synthase; Chain
Functional Family Isopenicillin N synthase

Enzyme Information

1.21.3.1
Isopenicillin-N synthase.
based on mapping to UniProt P05326
N-((5S)-5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine + O(2) = isopenicillin N + 2 H(2)O.
-!- Forms part of the penicillin biosynthesis pathway.

UniProtKB Entries (1)

P05326
IPNS_EMENI
Aspergillus nidulans FGSC A4
Isopenicillin N synthase

PDB Structure

PDB 1W04
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Studies on the Reaction of Isopenicillin N Synthase with the Truncated Substrate Analogues Delta-(L-Alpha-Aminoadipoyl)-L-Cysteinyl-Glycine and Delta-(L-Alpha-Aminoadipoyl)-L-Cysteinyl-D- Alanine
Long, A.J., Clifton, I.J., Roach, P.L., Baldwin, J.E., Schofield, C.J., Rutledge, P.J.
Biochemistry