CATH Domain 1vsnA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.70	Cathepsin B; Chain A
	3.90.70.10	Cysteine proteinases

Domain Context

CATH Clusters

Superfamily	Cysteine proteinases
Functional Family

Enzyme Information

3.4.22.38

Cathepsin K.

based on mapping to UniProt P43235

Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg.

-!- Prominently expressed in mammalian osteoclasts, and believed to play a role in bone resorption. -!- Belongs to peptidase family C1.

UniProtKB Entries (1)

P43235

CATK_HUMAN

Homo sapiens

Cathepsin K

PDB Structure

PDB	1VSN
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Pichia
Primary Citation	Identification of a potent and selective non-basic cathepsin K inhibitor. Li, C.S., Deschenes, D., Desmarais, S., Falgueyret, J.P., Gauthier, J.Y., Kimmel, D.B., McGrath, M.E., McKay, D.J., Percival, M.D., Riendeau, D., Rodan, S.B., Truong, V.L., Wesolowski, G., Zamboni, R., Black, W.C. Bioorg.Med.Chem.Lett.