CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.30 | Roll |
|
2.30.30 | SH3 type barrels. |
|
2.30.30.60 |
Domain Context
CATH Clusters
| Superfamily | 2.30.30.60 |
| Functional Family |
Enzyme Information
| 1.5.1.3 |
Dihydrofolate reductase.
based on mapping to UniProt P00383
5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH.
-!- The enzyme from animals and some micro-organisms also slowly reduces folate to 5,6,7,8-tetrahydrofolate. -!- Formerly EC 1.5.1.4.
|
UniProtKB Entries (1)
| P00383 |
DYR21_ECOLX
Escherichia coli
Dihydrofolate reductase type 2
|
PDB Structure
| PDB | 1VIE |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
A plasmid-encoded dihydrofolate reductase from trimethoprim-resistant bacteria has a novel D2-symmetric active site.
Nat.Struct.Biol.
|
