CATH Domain 1vh2A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.1360	Gyrase A; domain 2
	3.30.1360.80	S-ribosylhomocysteinase (LuxS)

Domain Context

CATH Clusters

Superfamily	S-ribosylhomocysteinase (LuxS)
Functional Family

Enzyme Information

4.4.1.21

S-ribosylhomocysteine lyase.

based on mapping to UniProt Q9RRU8

S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5- dihydroxypentan-2,3-dione.

-!- The 4,5-dihydroxypentan-2,3-dione formed spontaneously cyclizes and combines with borate to form an autoinducer (AI-2) in the bacterial quorum-sensing mechanism, which is used by many bacteria to control gene expression in response to cell density. -!- Formerly EC 3.2.1.148 and EC 3.3.1.3.

UniProtKB Entries (1)

Q9RRU8

LUXS_DEIRA

Deinococcus radiodurans R1

S-ribosylhomocysteine lyase

PDB Structure

PDB	1VH2
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Structural analysis of a set of proteins resulting from a bacterial genomics project Badger, J., Sauder, J.M., Adams, J.M., Antonysamy, S., Bain, K., Bergseid, M.G., Buchanan, S.G., Buchanan, M.D., Batiyenko, Y., Christopher, J.A., Emtage, S., Eroshkina, A., Feil, I., Furlong, E.B., Gajiwala, K.S., Gao, X., He, D., Hendle, J., Huber, A., Hoda, K., Kearins, P., Kissinger, C., Laubert, B., Lewis, H.A., Lin, J., Loomis, K., Lorimer, D., Louie, G., Maletic, M., Marsh, C.D., Miller, I., Molinari, J., Muller-Dieckmann, H.J., Newman, J.M., Noland, B.W., Pagarigan, B., Park, F., Peat, T.S., Post, K.W., Radojicic, S., Ramos, A., Romero, R., Rutter, M.E., Sanderson, W.E., Schwinn, K.D., Tresser, J., Winhoven, J., Wright, T.A., Wu, L., Xu, J., Harris, T.J. Proteins